包思琪，博士研究生

海南大学信息与通讯工程学院2021级博士

主要从事利用生物信息学技术和实验技术基于多组学数据识别包括眼部肿瘤在内的复杂疾病遗传和表观遗传致病因子和临床标记物。研究生期间共发表SCI收录论文11篇，以第一作者和并列第一作者身份发表SCI论文7篇（中科院一区TOP期刊论文4篇，中科院二区期刊论文3篇），累计影响因子56点。授权中国发明专利2项。荣获浙江省生物信息学会第七届学术年会论文二等奖。研究生期间获得研究生学业奖学金一等奖、硕士研究生国家奖学金、研究生卓越奖学金和高视远望“科研贡献”奖学金。获浙江省优秀硕士毕业生称号；生物信息学TOP1区杂志《Briefings in Bioinformatics》审稿人。

学习和研究经历

1、2013.09-2018.06，哈尔滨医科大学生物信息专业本科

2、2018.09-2021.06，温州医科大学生物医学工程专业硕士研究生

3、2021.09-至今，海南大学信息与通信工程专业博士研究生

主要研究论文

PUBLICATION(^# equally contribution and * corresponding author)

1、Bao S^#, Zhao H, Yuan J, Fan D, Zhang Z, Su J* & Zhou M* (2020): Computational identification of mutator-derived lncRNA signatures of genome instability for improving the clinical outcome of cancers: a case study in breast cancer. Brief Bioinform 21, 1742-1755.

2、Bao S^#, Hu T^#, Liu J^#, Su J, Sun J, Ming Y, Li J, Wu N*, Chen H* & Zhou M* (2021): Genomic instability-derived plasma extracellular vesicle- microRNA signature as non-invasive predictor of risk and unfavorable prognosis in breast cancer. J Nanobiotechnology 19, 22

3、Hou P^#, Bao S^#, Fan D^#, Su J, Qu J* & Zhou M* (2021): Machine learning-based integrative analysis of methylome and transcriptome identifies novel prognostic DNA methylation signature in uveal melanoma. Briefings in Bioinformatics, 2021,22(4): bbaa371

4、Sun J^#, Zhang Z^#, Bao S^#, Yan C, Hou P, Wu N, Su J, Xu L & Zhou M* (2020): Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer. J Immunother Cancer 8, e000110.

5、Sun J^#, Bao S^#, Xu D^#, Zhang Y, Su J, Liu J, Hao D* & Zhou M* (2019): Large-scale integrated analysis of ovarian cancer tumors and cell lines identifies an individualized gene expression signature for predicting response to platinum-based chemotherapy. Cell Death Dis 10, 661.

6、Zhou M^#, Zhang Z^#, Bao S^#, Hou P, Yan C, Su J* & Sun J* (2021): Computational recognition of lncRNA signature of tumor-infiltrating B lymphocytes with potential implications in prognosis and immunotherapy of bladder cancer. Briefings in Bioinformatics, 2021, 22(3): bbaa047

7、Wang X^#, Qian T^#, Bao S^#, Zhao H, Chen H, Xing Z, Li Y, Zhang M, Meng X, Wang C, Wang J, Gao H, Liu J, Zhou M* & Wang X* (2021): 1. Wang X, Qian T, Bao S, Zhao H, Chen H, Xing Z, et al. Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer. Molecular Oncology, 2021, 15(9):2466-2479.

8、Zhang Z^#, Bao S, Yan C, Hou P, Zhou M* & Sun J* (2021): Computational principles and practice for decoding immune contexture in the tumor microenvironment. Briefings in Bioinformatics, 2021, 22(3): bbaa075

9、Zhao H^#, Gu S^#, Bao S, Yan C, Zhang Z, Hou P, Zhou M* & Sun J* (2021): Mechanistically derived patient-level framework for precision medicine identifies a personalized immune prognostic signature in high-grade serous ovarian cancer. Briefings in Bioinformatics, 2021, 22(3): bbaa069

10、Yan C^#, Zhang Z, Bao S, Hou P, Zhou M, Xu C* & Sun J* (2020): Computational Methods and Applications for Identifying Disease-Associated lncRNAs as Potential Biomarkers and Therapeutic Targets. Mol Ther Nucleic Acids 21, 156-171.

11、Zhang Y^#, Yu F^#, Bao S & Sun J* (2019): Systematic Characterization of Circular RNA- Associated CeRNA Network Identified Novel circRNA Biomarkers in Alzheimer's Disease. Front Bioeng Biotechnol 7, 222.