樊丹丹，博士研究生

温州医科大学生物医学大数据研究所博士。主要从事表观遗传学研究，利用生物信息学和计算生物学方法，采用干湿实验结合的方式，挖掘人类复杂疾病致病基因，并探索其表观调控机制。目前研究方向有：（1）食管鳞癌发生发展过程中的表观遗传异常调控机制研究；（2）DNA调控元件如启动子、增强子、沉默子以及三维基因组在疾病发生过程中的功能研究。参与国家自然科学基金面上项目、浙江省自然科学基金等多项科研项目，共发表SCI论文7篇，其中以第一或并列第一作者在Nature Communications，Biefings in Bioinformatic 及 Investigative Ophthalmology & Visual Science 等权威期刊发表论文3篇。

电子邮箱：biofandd@gmailcom

学习和研究经历

1、2011.09-2016.07，哈尔滨医科大学生物信息学专业本科

2、2018.09-2021.07，温州医科大学生物医学工程专业硕士

3、2021.09-至今，温州医科大学生物医学工程专业博士

主要研究论文

PUBLICATION(^# equally contribution and * corresponding author)

1、Ye B^#, Fan D^#, Xiong W^#, Lin J, Yuan J, Jiang Q, Zhao Y, Li M, Liu J, Lv Y, Wang X, Li Z*, Su J*, Qiao Y*. Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis. Nature Communications, 2021, 12(1):4457.

2、Jian Yuan^#, Dandan Fan^#, Zhengbo Xue, Jia Qu*, Jianzhong Su*; Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19. Investigative Ophthalmology & Visual Science, 2020,61(12)

3、Hou P^#, Bao S^#, Fan D^#, Yan C, Su J, Qu J*, Zhou M*. Machine learning-based integrative analysis of methylome and transcriptome identifies novel prognostic DNA methylation signature in uveal melanoma. Briefings in Bioinformatics, 2021, doi: 10.1093/bib/bbaa371.

4、Jian Yuan^#, Qi Jiang^#, Tongyang Gong^#, Dandan Fan^#, Ji Zhang, Fukun Chen, Xiaolin Zhu, Xinyu Wang, Yunbo Qiao, Hongyan Chen*, Zhihua Liu*, Jianzhong Su*. Loss of grand histone H3 lysine 27 trimethylation domains mediated transcriptional activation in esophageal squamous cell carcinoma. NPJ genomic medicine, 2021,6(1):65

5、Jian Yuan^#, Fukun Chen^#, Dandan Fan^#, Qi Jiang, Zhengbo Xue, Ji Zhang, Xiangyi Yu, Kai Li, Jia Qu*, Jianzhong Su*. EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases. NAR Genomics and Bioinformatics, 2021,3(2),lqab050.

6、Bao S^#, Zhao H, Yuan J, Fan D, Zhang Z, Su J^*, Zhou M*. Computational identification of mutator-derived lncRNA signatures of genome instability for improving the clinical outcome of cancers: a case study in breast cancer. Briefings in Bioinformatics, 2020, 21(5):1742-1755.

7、Jian Yuan^#, Yu-Yu Li^#, Yi Xu, Bian-Jin Sun, Jiao Shao, Die Zhang, Kai Li, Dan-Dan Fan, Zheng-Bo Xue, Wei-Hua Chen, Clara Pak, Yong-Liang Lou, Jian-Zhong Su*, Mei-Qin Zheng*. Molecular Signatures Related to the Virulence of Bacillus cereus Sensu Lato, a Leading Cause of Devastating Endophthalmitis. mSystems, 2019,4(6).