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马云龙

发布时间:2020-04-22 15:01:59 浏览量:4323

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马云龙 博士

马云龙,副研究员、硕士生导师,入选温州市“瓯越英才计划”项目。毕业于浙江大学遗传学博士、生物信息学博士后。现担任浙江省生物信息学学会青年委员会常委, 健康大数据与转化医学专委会委员。主要利用生物信息学、遗传学、人工智能和实验生物技术在多学科交叉领域研究复杂疾病(眼脑疾病)的遗传分子机制和诊疗方法。目前研究方向: 1)遗传单细胞测序数据分析及算法开发,2) 遗传队列及家系构建及致病突变的筛查。至今在Genome Medicine (IF=15.27)、Ophthalmology (IF=14.28)、Molecular Cancer (IF=44.4)、Psychological Medicine (IF=10.59)、Journal of Nanobiotechnology (IF=10.44)、Cell Reports (IF=9.995)、Briefings in Bioinformatics (IF=13.994)、Molecular Neurobiology (IF=5.68)、Human Molecular Genetics (IF=6.15)和Translational Psychiatry (IF=7.99)等国际期刊上累计发表40篇SCI收录研究论文(其中第一和通讯作者25篇),影响因子IF > 200。拥有4项生物信息学分析软件著作权及6项发明专利,获得2021、2022年度浙江省生物信息学会自然科学奖一等奖及科技进步奖二等奖,讲授《生物医学编程技术》大学生课程。受邀参加国内外会议100余次。担任Genome Medicine、 Nature Communications、 Nature Cardiovascular Research、 eBioMedicine、 eLife、 Clinical and Translational Medicine、 Translational Psychiatry、Briefings in Bioinformatics等多个SCI期刊的审稿人。相关研究成果被Nature新闻部、 New Scientist、美国洛杉矶时报、Daily Times、HealthDay News等多家新闻媒体作特别报道。

电子邮箱:glb-biotech@zju.edu.cn 或者 myl_genomics@wmu.edu.cn


 

研究经历

1、2021年01月-至今,温州医科大学生物医学大数据研究所 副研究员

2、2020年03月-2020年12月,温州医科大学生物医学大数据研究所 助理研究员

3、2017年10月-2019年11月,浙江大学医学院附属第一医院 博士后

4、2012年09月-2017年06月,浙江大学医学院附属第一医院 博士

 

社会任职

1、2016年08月-至今,美国人类遗传学会会员

2、2018年10月-至今,浙江省生物信息学学会青年委员会常委

3、2020年09月-至今,中国医药数学学会会员

4、2020年10月-至今,中国计算机学会(CCF)会员

5、2021年05月-至今,浙江省生物信息学学会健康大数据与转化医学专委会委员


发明专利

1、重症新型冠状肺炎患者的诊断标志物,专利号:ZL202111290271.1。

 

代表性研究论文 (#共同一作, *通讯作者)

1. Ma Yunlong#, Qiu F#, Deng C#, Li J#, Huang Y#, Wu Z, Zhou Y, Zhang Y, Xiong Y, Yao Y, Zhong Y, Qu J, Su J*. Integrating single cell sequencing data with GWAS summary statistics reveals CD16+monocytes and memory CD8+T cells involved in severe COVID-19. Genome Medicine. 2022 Feb 17;14(1):16. doi: 10.1186/s13073-022-01021-1. (第一作者,IF=15.27, 中科院1区.

2. Xiang B#, Deng C#, Qiu F#, Li J, Li S, Zhang H, Lin X, Huang Y, Zhou Y, Su J, Lu M*, Ma Yunlong*. Single cell sequencing analysis identifies genetics-modulated ORMDL3+ cholangiocytes having higher metabolic effects on primary biliary cholangitis. Journal of Nanobiotechnology. 2021 Dec 6; 19(1):406. doi: 10.1186/s12951-021-01154-2. (通讯作者,IF=10.44, 中科院1区

3. Xu L#, Ma Yunlong#, Yuan J#, Zhang Y#, Wang H#, Zhang G, Tu C, Lu X, Li J, Xiong Y, Chen F, Liu X, Xue Z, Zhou M, Li W, Wu N, Bao J, Chen H, Lu F*, Su J*, Qu J*. COVID-19 quarantine reveals that behavioral changes have an effect on myopia progression. Ophthalmology, 2021 Nov;128(11):1652-1654. doi: 10.1016/j.ophtha.2021.04.001. (共同一作,IF=14.28, 中科院1区.

4. Ma Yunlong#, Huang Y#, Zhao S, Yao Y, Zhang Y, Qu J, Wu N*, Su J*. Integrative genomics analysis reveals a 21q22.11 locus contributing to susceptibility of COVID-19. Human Molecular Genetics, 2021 May 5; ddab125. doi: 10.1093/hmg/ddab125. (第一作者,IF=6.15, 中科院2区.  

5. Ma Yunlong, Wang M, Yuan W, Su K, Li M*. The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale Meta-analysis of Caucasian populations. Translational Psychiatry, 2015 Dec 1; 5(12):e686. doi: 10.1038/tp.2015.176. (第一作者,IF=7.99, 中科院1区.

6. Ma Yunlong, Yuan Y, Jiang X, Cui W*, Li M*. Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. Molecular Neurobiology, 2015 Feb; 51(1):281-99. doi: 10.1007/s12035-014-8826-2 (第一作者,IF=5.68, 中科院2区.

7. Ma Yunlong, Wen L, Cui W, Yuan W, Yang Z, Jiang K, Jiang X, Huo M, Sun Z, Han H, Su K, Yang S, Payne T, Wang J*, Li M*. Prevalence of cigarette smoking and nicotine dependence in men and women residing in two provinces in China. Frontiers in Psychiatry, 2017 Dec 1;8: 254. doi: 10.3389/fpsyt.2017.00254 (第一作者,IF=5.44, 中科院2区.

8. Huang Y#, Luo J#, Zhang Y, Zhang T, Fei X, Chen L, Zhu Y, Li S, Zhou C, Xu K, Ma Yunlong*, Lin J*, Zhou J*. Identification of MKNK1 and TOP3A as ovarian endometriosis risk-associated genes using integrative genomic analyses and functional experiments. Computational and Structural Biotechnology Journal. 2023 Feb 5;21:1510-1522. doi: 10.1016/j.csbj.2023.02.001. (通讯作者,IF=7.23, 中科院2区.

9. Ma X, Wang P, Xu G, Yu F*, Ma Yunlong*. Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma. BMC Medical Genomics, 2020 Aug 31; 13(1):123. doi: 10.1186/s12920-020-00768-z (通讯作者,IF=3.62, 中科院3区.

10. Liu Q#, Hou A#, Zhang Y, Guo Y, Li J, Yao Y, Niu K, Li H, Ma Yunlong*, Cao J*. MiR-190a potentially ameliorates postoperative cognitive dysfunction by regulating Tiam1. BMC Genomics, 2019 Aug 22; 20(1):670. doi: 10.1186/s12864-019-6035-0. (通讯作者,IF=4.55, 中科院2区.

11. Lv Y#, Xu X, Wang Z, Huang Y, Ma Yunlong*, Wu M*, Integrated multi-omics data analysis identifies a novel genetics-risk gene of IRF4 associated with prognosis of oral cavity cancer. Current Bioinformatics, 2022. pp.744-758(15). (通讯作者,IF = 4.85, 中科院3区.

12. Zhang Y#, Ma Yunlong#, Huang Y, Zhang Y, Jiang Q, Zhou M, Su J*. Benchmarking algorithms for pathway activity transformation of single-cell RNA-seq data. Computational and Structural Biotechnology Journal. 2020 Oct 15; 18:2953-2961. doi: 10.1016/j.csbj.2020.10.007. (共同一作,IF=7.23, 中科院2区.

13. Hu H, Feng Z, Lin H, Zhao J, Zhang Y, Xu F, Chen L, Chen F, Ma Yunlong, Su J, Zhao Q*, Shuai J*. Modeling and analyzing single-cell multimodal data with deep parametric inference. Briefings in Bioinformatics. 2023 Jan 19;24(1):bbad005. doi: 10.1093/bib/bbad005. (参与作者,IF=13.994, 中科院1区.

14. Liu J#, Zhao H#, Huang Y#, Xu S#, Zhou Y, Zhang W, Li J, Ming Y, Wang X, Zhao S, Li K, Dong X, Ma Yunlong, Qian T, Xing Z, Zhang Y, Chen H, Liu Z, Pang D, Zhou M, Wu Z, Wang X, Wang X*, Wu N*, Su J*. Genome-wide cell-free DNA methylation analyses improve accuracy of non-invasive diagnostic imaging for early-stage breast cancer. Molecular Cancer. 2021 Feb 19; 20(1):36. doi: 10.1186/s12943-021-01330-w. (参与作者,IF=44.4, 中科院1区.

15. Su J#, Yuan J#, Xu L#, Xing S#, Sun M#, Yao Y, Ma Yunlong, Chen F, Jiang L, Li K, Yu Y, Xue Z, Zhang Y, Fan D, Zhang J, Liu H, Liu X, Zhang G, Wang H, Zhou M, Lyu F, An G, Yu X, Xue Y*, Yang J*, and Qu J*, Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population. Cell Reports. 2023. (参与作者,IF=9.9953, 中科院1区.

16. Ma Yunlong, Yuan W, Cui W*, Li M*. Meta-analysis reveals significant association of 3′-UTR VNTR in SLC6A3 with smoking cessation in Caucasian populations. The Pharmacogenomics Journal. 2016 Feb; 16(1):10-7. doi: 10.1038/tpj.2015.44. (第一作者,IF=3.55, 中科院2区.

17. Ma Yunlong#, Fan R#, Li M*. Meta-analysis reveals significant association of the 3’-UTR VNTR in SLC6A3 with alcohol dependence. Alcoholism-Clinical and Experimental Research. 2016 Jul;40(7):1443-53. doi: 10.1111/acer.13104. (第一作者,IF=3.93, 中科院3区.

18. Ma Yunlong, Li M*. Establishment of a strong link between smoking and cancer pathogenesis through DNA methylation analysis. Scientific Reports. 2017 May 12;7(1):1811. doi: 10.1038/s41598-017-01856-4. (第一作者,IF=4.9967, 中科院3区.

19. Yao Y, Xu Y, Cai Z, Liu Q, Ma Yunlong, Li A, Payne T., Li M*. Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression. Psychological Medicine. 2021 Aug;51(11):1870-1879. doi: 10.1017/S003329172000063X. (参与作者,IF=10.5915, 中科院1区.

20. Xu L#, Zhuang Y#, Zhang G#, Ma Yunlong#, Yuan J#, Tu C, Li M, Wang W, Zhang Y, Lu X, Li J, Liu X, Xue Z, Zhou M, Sun J, Bao J, Li M, Lu F*, Wang H*, Su J*, Qu J*. Design, methodology, and baseline of whole city-million scale children and adolescents myopia survey (CAMS) in Wenzhou, China. Eye and Vision, 2021 Aug 19; 8(1):31. doi: 10.1186/s40662-021-00255-1. (共同一作,IF=4.43, 中科院1区.

21. Dong Z#, Ma Yunlong#, Zhou H, Shi L, Ye G, Yang L, Liu P, Zhou L*. Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets. BMC Pulmonary Medicine. 2020 Oct 16;20(1):270. doi: 10.1186/s12890-020-01303-7. (共同一作,IF=3.32, 中科院3区.

22.  Liu Q#, Han H#, Wang M, Yao Y, Wen L, Jiang K, Ma Yunlong, Fan R, Chen J, Su K, Yang Z, Cui W, Yuan W, Jiang X, Li J, Payne T, Wang J, Li M*. Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population. Translational Psychiatry. 2018 Apr 18;8(1):83. doi: 10.1038/s41398-018-0130-x. (参与作者,IF=7.99, 中科院1区.

23. Han H#, Liu Q#, Yang Z, Wang M, Ma Yunlong, Cao L, Cui W, Yuan W, Payne T, Li L*, Li M*. Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers. Translational Psychiatry. 2018 Nov 7;8(1):243. doi: 10.1038/s41398-018-0290-8. (参与作者,IF=7.99, 中科院1区.


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