袁健 博士

温州医科大学附属眼视光医院/生物医学大数据研究所助理研究员。主要从事利用遗传学、表观功能基因组学和计算生物学的方法，采用干湿实验结合的方式，发现人类疾病中致病基因以及表观遗传调控机制，进行机制的探索和临床的转化研究。目前研究方向：（1）视网膜病变，高度近视等眼部复杂疾病的遗传机制；（2）DNA调控元件如启动子、增强子、沉默子以及三维基因组在疾病形成过程中的表观调控机制。先后参加国家自然科学基金面上项目、浙江省自然科学基金等多项科研项目。近年来，在国际主流期刊发表SCI论文20篇，其中以第一或并列第一作者在Ophthalmology，Investigative Ophthalmology & Visual Science上发表论文。担任Biefings in Bioinformatics，Frontiers in Ecology and Evolution等期刊审稿人。

电子邮箱：danielwyuan@gmail.com。办公电话：0577-88068271。

学习和研究经历

1、2007.09-2011.07 闽南师范大学生物科学专业本科

2、2011.09-2014.07 安徽师范大学细胞生物学专业硕士研究生

3、2014.09-2017.12 北京大学生物学专业博士研究生

4、2018.01-至今       温州医科大学大数据研究所助理研究员

承担科研项目

1、国家自然科学基金面上项目（61871294），泛癌症异常DNA甲基化标志物识别及其调控机制研究，2019.1-2022.12，主要参与人，经费63万元，在研。

2、国家自然科学基金面上项目（82172882），融合多组学数据挖掘食管鳞癌超级抑制子致病基因及其调控机制研究 ，2022.01.01-2025.12.31，主要参与人，经费55万元，在研。

主要研究论文

Zhengbo Xue#, Jian Yuan#, Fukun Chen#, Yinghao Yao, Shilai Xing, Xiangyi Yu, Kai Li, Chenxiao Wang, Jinhua Bao, Jia Qu, Jianzhong Su*, Hao Chen*. eBioMedicine,2022,82:104161

Liangde Xu#, Youyuan Zhuang#, Guosi Zhang#, Yunlong Ma#, Jian Yuan#, Changseng Tu, MiaoMiao Li, Wencan Wang, Yaru Zhang, Xiaoyan Lu, Jing Li, Xinting Liu, Zhengbo Xue, Meng Zhou, Jie Sun, Jinhua Bao, Ming Li, Fan Lu*, Hong Wang*, Jianzhong Su*, Jia Qu*. Design, methodology, and baseline of whole city-million scale children and adolescents myopia survey (CAMS) in Wenzhou, China. Eye and Vision, 2021,8(1):31

Jian Yuan#, Qi Jiang#, Tongyang Gong#, Dandan Fan#, Ji Zhang, Fukun Chen, Xiaolin Zhu, Xinyu Wang, Yunbo Qiao, Hongyan Chen*, Zhihua Liu*, Jianzhong Su*. Loss of grand histone H3 lysine 27 trimethylation domains mediated transcriptional activation in esophageal squamous cell carcinoma. NPJ genomic medicine, 2021,6(1):65

Jian Yuan#, Fukun Chen#, Dandan Fan#, Qi Jiang, Zhengbo Xue, Ji Zhang, Xiangyi Yu, Kai Li, Jia Qu*, Jianzhong Su*. EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases. NAR Genomics and Bioinformatics, 2021,3(2),lqab050

Liangde Xu#, Yunlong Ma#, Jian Yuan#, Yaru Zhang#, Hong Wang#, Guosi Zhang, Changsheng Tu, Xiaoyan Lu, Jing Li, Yichun Xiong, Fukun Chen, Xinting Liu, Zhengbo Xue, Meng Zhou, Wen-Qing Li, Nan Wu, Jinhua Bao, Hao Chen, Fan Lu, Jianzhong Su*, Jia Qu*. COVID-19 Quarantine Reveals Grade-specific Behavioral Modification of Myopia. Ophthalmology, 2021,S0161-6420(21)00257-8 

Na Chen#, Sen Zhao#, Angad Jolly#, Lianlei Wang#, Hongxin Pan#, Jian Yuan, Shaoke Chen, André Koch, Congcong Ma, Weijie Tian, Ziqi Jia, Jia Kang, Lina Zhao, Chenglu Qin, Xin Fan, Katharina Rall, Zeynep Coban-Akdemir, Zefu Chen, Shalini Jhangiani, Ze Liang, Yuchen Niu, Xiaoxin Li, Zihui Yan, Yong Wu, Shuangshuang Dong, Chengcheng Song, Guixing Qiu, Shuyang Zhang, Pengfei Liu, Jennifer E Posey, Feng Zhang, Guangnan Luo, Zhihong Wu, Terry Jianguo Zhang, Nan Wu, Shengru Wang, Jiaqi Liu, Sen Liu, Yuzhi Zuo, Gang Liu, Chenxi Yu, Lian Liu, Jiashen Shao, Hengqiang Zhao, Huizi Wang, Bowen Liu, Xi Cheng, Jiachen Lin, Huakang Du, Yaqi Li, Shuang Song, Zhixin Xie, Zhengye Zhao, Zhi Zhao, Zhifa Zheng, Yingzhao Huang, Jianzhong Su, Jianguo Zhang, Eugenia Y Chen, Konstantinos Rouskas, Stavros Glentis, Flora Bacopoulou, Efthymios Deligeoroglou, George Chrousos, Stanislas Lyonnet, Michel Polak, Carla Rosenberg, Irene Dingeldein, Ximena Bonilla, Christelle Borel, Richard A Gibbs, Jennifer E Dietrich, Antigone S Dimas, Stylianos E Antonarakis, Sara Y Brucker, James R Lupski*, Lan Zhu*. Perturbations of genes essential for Müllerian duct and W?lffian duct development in Mayer-Rokitansky-Küster-Hauser syndrome. The American Journal of Human Genetics, 2021, S0002-9297(20)30450-X

Jian Yuan#, Dandan Fan#, Zhengbo Xue, Jia Qu*, Jianzhong Su*; Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19. Investigative Ophthalmology & Visual Science, 2020,61(12)

Jian Yuan#, Yu-Yu Li#, Yi Xu, Bian-Jin Sun, Jiao Shao, Die Zhang, Kai Li, Dan-Dan Fan, Zheng-Bo Xue, Wei-Hua Chen, Clara Pak, Yong-Liang Lou, Jian-Zhong Su*, Mei-Qin Zheng*.Molecular Signatures Related to the Virulence of Bacillus cereus Sensu Lato, a Leading Cause of Devastating Endophthalmitis. mSystems, 2019,4(6).

Junjie Luo#, Yirong Wang#, Jian Yuan#, Zhilei Zhao, Jian Lu*. MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution. RNA, 2018,24: 787-802.

Jian Yuan, Lei Zhang, Xianzhao Kan*, Lan Jiang, Jianke Yang, Zhichun Guo, Q-Q Ren. Origin and molecular characteristics of a novel 2013 avian influenza A (H6N1) virus causing human infection in Taiwan. Clinical Infectious Diseases, 2013,57: 1367-1368.